GLP-1 drugs like semaglutide (Ozempic, Wegovy) and tirzepatide (Mounjaro, Zepbound) have changed the game thanks to groundbreaking advancements in weight loss medications
Notably, it is well established that glucagon-like peptide-1 (GLP-1), an incretin hormone of the glucagon superfamily, contributes to glucose-dependent pancreatic -cell insulin secretion
The study randomized 1,949 participants in a 1:1:2 ratio to receive retatrutide 9 mg, 12 mg, or placebo
Endocrinology 166:bqaf028 Kaur M, Misra S (2024) A review of an investigational drug retatrutide, a novel triple agonist agent for the treatment of obesity
Salminen, A., Hyttinen, J
In fact, restriction can increase stress hormones, slow metabolism, and make recovery more difficult